Using qPCR, the SNCA-induced disturbances observed by RNA-seq were confirmed for selected genes such as Slc6a11, Slc5a7, and Aldh1a1. While Slc6a11 and Slc5a7 are membrane-bound transporters related to GABA and cholinergic signaling pathways, respectively, Aldh1a1 is involved in alcohol metabolism and other environment-induced metabolic responses, with an implication in PD and AD pathophysiology (Wey et al., 2012; Grunblatt and Riederer, 2016). This evidence concerns the gene ALDH1A1 and Alzheimer disease.