INS and Glucose intolerance: Although we did not evaluate the in vivo insulin secretion under ipGTT experiment, the suggestive insulin hypersecretion observed by our hyperinsulinemic rats was not enough to prevent glucose intolerance and this is supported by previous studies (Giozzet et al., 2008; Angelini et al., 2010; Protzek et al., 2014; dos Santos et al., 2014), an effect that was not exacerbated in 6-OHDA-treated rats.