Cancer is distinguished by the overexpression of PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6 Bisphosphotase 3) enzyme which will enhance the glycolytic activity–a Warburg effect, whereas in AD, the expression of PFKFB3 in astrocyte, diminishes with age, and as a result, the process of the oxidative phosphorylation is upregulated–an inverse Warburg effect, to compensate the metabolic energy demands. The gene discussed is PFKFB3; the disease is cancer.