It is also seen that the oxidative stress can also be a cause for the oxidation of PPIase and thus the total PPIase concentration is lower in neuron and this contributes to the hyperphosphorylation of tau by regulating the activities of GSK3β and PP2A, resulting in the pathogenesis of AD (Blair et al., 2015). This evidence concerns the gene FKBP3 and Alzheimer disease.