IGF1 and Insulin resistance: Scientific data portrays that deregulation of Insulin/insulin-like growth factor 1 (IGF-1) signaling leads to neurodegenerative disorders such as AD (Salminen and Kaarniranta, 2010) and several other diseases like cancer (Heni et al., 2012), diabetes, (Fowlkes et al., 2011), etc. Current hypotheses and theories implicate that insulin resistance (IR) is one of the prime cause for the severity of AD.