Second, cytokines such as interleukin-3 or interleukin-6 which plays an important role in the pathophysiology of ischemic stroke influence megakaryocyte ploidy which in turn affect the platelet size and can lead to the production of more reactive, larger platelets [28] and so the proinflammatory condition before the ischemic stroke may lead to a higher MPV which in turn lead to prothrombotic condition. The gene discussed is IL6; the disease is ischemic stroke.