Cholesterol metabolism has previously been implicated in AD (Di Paolo and Kim, 2011, Puglielli et al., 2003) and CE, the esterified storage products of cholesterol, accumulate in AD patient brains (Chan et al., 2012) and in APP-transgenic mice (Chan et al., 2012, Tajima et al., 2013, Yang et al., 2014). Here, APP is linked to Alzheimer disease.