MAPT and Mental deterioration: Regulation of pTau by CYP46A1 is also conserved in adult (mice) brains where genetic inhibition of CYP46A1 enhances abnormal phosphorylation of Tau (Djelti et al., 2015), and overexpression of CYP46A1 in transgenic Tau mice rescues cognitive decline (Burlot et al., 2015).