FLT3 and acute myeloid leukemia: We recently reported that novel dual FLT3-Src-family kinase inhibitors (see Fig. 1) that contain alkynyl aminoisoquinoline moiety potently inhibited FLT3-ITD harboring AML cell lines, such as MV4–11 and MOLM-14, with single digit nanomolar or even sub-nanomolar half maximal inhibitory concentration (IC50) values in vitro [24].