Both oleic acid and palmitic acid trigger non-canonical autophagic response in human cancer cells, but through different mechanisms (beclin-1-independent autophagy that requires intact Golgi apparatus or via the activity of 5’AMP-activated protein kinase (AMPK), protein kinase R (PKR) and c-Jun N-terminal protein kinase 1 (JNK1)) [95]. The gene discussed is EIF2AK2; the disease is cancer.