Lan et al. compared invasive and non-invasive pituitary adenomas and found that the DPCR1 (diffuse panbronchiolitis critical region 1), EGFL7 (EGF like domain multiple 7), PRDM family (PR/SET domain family), and LRRC50 (leucine rich repeat containing 50) can function as genetic modifiers and most likely contribute to the development of oncocytic change and invasive tumor phenotype [19]. The gene discussed is EGFL7; the disease is neoplasm.