Since WT Tau and P301L cells show identical up-regulation of UPR genes and dysfunction of mitochondrial bioenergetics after acute thapsigargin treatment, fluorescence intensity of AT8 antibody, which detects specific epitopes of phospho-tau (Ser202, Thr205) that have been widely suggest to contribute in AD progression, was measured by immunocytochemistry under the confocal microscopy. The gene discussed is MAPT; the disease is Alzheimer disease.