We observed a significantly higher frequency of PD-L1/PD-L2-involving genetic aberrations in EBV-positive DLBCL (5 of 27) than in EBV-negative DLBCL (1 of 48) (P < 0.05) (Fig. 4a, b). This evidence concerns the gene PDCD1LG2 and diffuse large B-cell lymphoma.