Prostate cancer is also considered as hormone-dependent and associated with BRCA1/2 mutations, but interestingly, we only observed a nominally significant and modest (rg = 0.07) genetic correlation between breast and prostate cancer, while ovarian and prostate cancer showed no genetic correlation (rg = 0.02, se = 0.07). Here, BRCA1 is linked to Familial prostate cancer.