CCL2 and cancer: Senescence-associated secretory phenotype (SASP) is defined by production of CCL2/MCP1, TNFα, IFNγ, IL-6, growth and differentiation factors (TGFβ and HGF), and matrix remodeling enzymes (metalloproteinases; MMP1/3/10/13) and is implicated in cancer growth and organ regeneration5,6.