Several variants were indeed detected in the normal controls (200 normal fertility males) (Supplementary Table 1), whereas those rare and deleterious heterozygous mutations of QRICH2 were found only in asthenospermia (asthenozoospermia: 6/150; control: 0/200; p < 0.006, the Fisher exact test, two-sided), indicating that deleterious heterozygous mutations of QRICH2 may increase the risk of asthenospermia. Here, QRICH2 is linked to Reduced sperm motility.