To determine the function of Cbfβ-deficient ILC2s in the chronic allergy model, mice were continuously administered a high dose of papain every three days for one month as a severe chronic allergy model (Supplementary Fig. 7c) or a high dose of papain every three days three times followed by the same course of papain treatment after a two week cessation period as a repeated chronic allergy model (Supplementary Fig. 7d). Here, CBFB is linked to allergic disease.