Although previous research on myeloma has indicated that NSD2 can affect the enhancer of zeste homologue 2 (EZH2, a methyltransferase), increase histone 3 lysine 27 trimethylation (H3K27me3) levels and ultimately lead to repression of gene expression15,16, the results in our study indicated that H3K27me3 levels were not changed significantly by knockdown of NSD2 (Fig. S1) which is in accordance with the results of Kuo et al.9. Here, NSD2 is linked to plasma cell myeloma.