To explore the role of CKIP-1 in the foam cell formation, wild-type (WT) and Ckip-1−/− BMDMs were incubated with oxLDL or serum from atherosclerosis-prone apolipoprotein E-deficient (Apoe−/−) mice, which contained atherogenic lipoprotein to induce foam cell formation. This evidence concerns the gene APOE and atherosclerosis.