IL1RN and craniosynostosis: Although the overall group effect was not significant for any of the markers studied in SAT when compared to the control group, only the effect of FF on decreasing IL1RN mRNA expression in SAT was significant (β-coefficient ± SD: −0.41 ± 0.18, P = 0.03; STable 5), but not in the other study groups (P > 0.15 for both LF and CSO) in relation to the control group.