CDH2 and nasopharyngeal carcinoma: Indeed, depletion of SHROOM2 by two shRNAs in two NPC cell lines, HONE1 and SUNE1 led to EMT as evidenced by downregulation of epithelial markers E-cadherin and β-catenin and upregulation of mesenchymal markers N-cadherin and fibronectin (Fig. 5d).