PARP1 and colorectal carcinoma: Decreased viability of CRC cells correlated with diminished proliferation (Fig. 2b) and late apoptosis, as observed by PARP-1 cleavage and annexin-V+/PI+ staining after 48 h (Fig. 2c, d), however, the pan-caspase inhibitor Z-VAD-FMK was unable to revert the decreased viability both at 24 h and 48 h (Supp Fig. 1A).