A parallel time-to-event Cox analysis confirmed inferior LFS in patients with IDH1 mutation (HR 4.3), SRSF2 mutation (HR 3.0), ASXL1 mutation (HR 2.0), circulating blasts ≥ 3% (HR 3.3), age > 70 years (HR 2.1), and presence of sex-adjusted moderate or severe anemia (HR 1.9). The gene discussed is IDH1; the disease is anemia (phenotype).