Using the results from the Cox time-to-event multivariable analysis, a predictive model for LT was devised, with point allocations commensurate with HR values; IDH1 (HR 4.3; 3 points), circulating blasts ≥ 3% (HR 3.3; 2 points), SRSF2 mutations (HR 3.0; 2 points), age > 70 years (HR 2.1; 1 point), ASXL1 mutations (HR 2.0; 1 point) and sex-adjusted moderate or severe anemia (HR 1.9; 1 point). This evidence concerns the gene IDH1 and anemia.