SMAD7 and myalgic encephalomeyelitis/chronic fatigue syndrome: Overexpression of miR-10a could up-regulate TGF-βl but down-regulate Smad7 expression in AF rats and CFs, whereas inhibiting miR-10a resulted in an opposite trend, which suggested that miR-10a may activate the TGF-βl/Smads signaling pathway to promote cardiac fibrosis.