In the second week after cancer cell inoculation, plasma concentrations of SDC-1, ESM-1 and sVCAM-1 (Figs 2A and 3A) diminished to values observed in control animals, while plasma concentration of Angpt-2 rose from 146.17±8.31 to 228.93±8.57 pmol/ml (Fig. 4A). The gene discussed is ESM1; the disease is cancer.