In the lungs, during the fifth week after tumour cell inoculation, the concentration of certain proteins increased, e.g. SDC-1 increased from 1.51±0.21 to 5.00±0.60 pmol/ml, VCAM-1 rose from 2.00±0.32 to 4.68±0.50 pmol/ml, E-sel was elevated from 191.53±19.06 to 597.49±54.05 pmol/ml, Angpt-2 increased from 72.12±6.88 to 219.88±33.25 pmol/ml, FLT-1 increased from 27.88±2.62 to 95.20±13.62 pmol/ml and PAI-1 rose from 43.00±3.60 to 142.70±13.62 pmol/ml (panel B in Figs 2-5). Here, FLT1 is linked to neoplasm.