In turn, the primary tumours in the late phase of metastasis exhibited high concentrations of ESM-1 (fourth week: 31.10±6.59 pmol/ml, fifth week: 14.93±2.94 pmol/ml), VCAM-1 (fourth week: 5.92±0.63 pmol/ml, fifth week: 4.73±0.24 pmol/ml), FLT-1 (fourth week: 104.52±13.97 pmol/ml, fifth week: 56.38±3.50 pmol/ml), ADM (fourth week: 13.44±1.04 pmol/ml, fifth week: 12.73±1.21 pmol/ml) as well as vWF (fourth week: 898.23±94.63 pmol/ml, fifth week: 1325.87±132.45 pmol/ml) (panel B in Figs 2-5). The gene discussed is VWF; the disease is neoplasm.