VWF and neoplasm: Accordingly, pulmonary endothelium of metastatic lungs seems to contribute to the number of plasma biomarkers raised during the late phase of metastasis (PAI-1, Angpt-2, sFLT-1, sE-sel), whereas primary tumours were an important source of vWF, the concentration of which progressively increased in primary tumours and in plasma along with the progression of breast cancer.