Hinson et al. (2000) and Oehler et al. (2003) reported that ADM plays an important role in tumour angiogenesis in breast cancer by increasing the intra-tumour blood flow as well as the development of lymph node metastases. In fact, in our hands, we detected an increased concentration of ADM not only in plasma, but also in the primary tumour, suggesting that the growing primary breast tumour might have contributed to the increased plasma concentration of this molecule (Keleg et al., 2007). This evidence concerns the gene ADM and breast neoplasm.