SELE and cancer: Interestingly, the concentration of E-sel in the lungs was also considerably raised, suggesting that pulmonary endothelium could constitute the major cellular origin of sE-sel during the late phase of pulmonary metastasis (Fig. 3), in agreement with a number of reports showing the role of sE-sel in cancer cell progression, for example in homing of metastatic cancer cells (Gogali et al., 2010).