Accordingly, pulmonary endothelium of metastatic lungs seems to contribute to the number of plasma biomarkers raised during the late phase of metastasis (PAI-1, Angpt-2, sFLT-1, sE-sel), whereas primary tumours were an important source of vWF, the concentration of which progressively increased in primary tumours and in plasma along with the progression of breast cancer. This evidence concerns the gene VWF and breast cancer.