Lysosome/autophagy dysfunction is further implicated as a link between LSDs and PD based on findings that heterozygous mutations in LSD-related genes are overrepresented in patients with sporadic PD, including in the SL degradative genes GBA1, ASAH1, SMPD1, and GALC (Fig. 3) (47, 48). This evidence concerns the gene GBA1 and Parkinson disease.