In this meta-analysis, using the Venice criteria results, we identified four variants with strong (TLR1 rs5743551-7202A/G, RAGE rs1800625-429 T/C and rs1800624-374 T/A, and miR-608 rs4919510G/C) and 14 variants with moderate levels of cumulative epidemiological evidence of associations with the risk of sepsis. This evidence concerns the gene TLR1 and Sepsis.