The primary meta-analysis of the four studies showed significant associations between the risk of sepsis and RAGE rs1800625-429 T/C in all three genetic models (OR = 0.59, 95% CI = 0.45–0.73, P < 0.001 for the dominant model, OR = 0.47, 95%CI = 0.24–0.96, P = 0.04 for the recessive model, and OR = 0.61, 95%CI = 0.51–0.74, P < 0.0001 for the allelic model) with a high level of evidence. This evidence concerns the gene AGER and Sepsis.