SLC25A22 and ovarian serous adenocarcinoma: Interestingly, one cell line insensitive to both paralog-specific knockouts (ovarian serous adenocarcinoma cell line JHOS-2, colored in black) is one of the most dependent cell line for the guide targeting SLC25A18 with an off-target to SLC25A22. This suggests some cell-line specific synthetic lethality, or at least some level of synergy, between the two paralogs.