MAP2K1 and melanoma: The authors found a coessentiality network cluster that is highly specific to BRAF-mutated melanoma cell lines and contains elements of the MAP kinase pathway (MAP2K1, MAPK1, and DUSP4) as well as SOX9 and SOX10. Using the CERES scores from the Achilles dataset, we were able to recreate the cluster entirely by taking the nine top genes correlated with the BRAF CERES score: BRAF, MITF, MAPK1, PEA15, NFATC2, ZEB21, DUSP4, SOX9, and SOX10 (Fig. 5e).