Although an increased number of monocytes was found in the bone marrow and spleens of mice bearing CT26-SDCSC-derived tumors, nevertheless, the percentage of monocytes in both the spleens and tumors from SDCSC-tumor bearing mice was not increased over that in spleens and tumors from mice bearing parental-derived tumors (Fig. 2c), indicating potential roles of neutrophils in the tumorigenesis of CRCSCs. This evidence concerns the gene DDX53 and neoplasm.