Another study showed that inhibition of miR-140-5p expression leads to contribution of linc00515 to upregulation of AGT14 in MM cells, which results in promotion of MM chemoresistance to melphalan, and vice versa; knockdown of linc00515 leads to AGT14 downregulation and inhibition of myeloma autophagy [92]. The gene discussed is ENSG00000260583; the disease is plasma cell myeloma.