Therefore, the blockade of PD-1/PD-L1 signaling has been shown to promote Th2 cell responses and Th2-type inflammations [13,40], which suggests that immune checkpoint blockade has the potential to modulate the balance between cellular immune response and humoral immune response and may lead to the onset of MG (Figure 5B). The gene discussed is CD274; the disease is myasthenia gravis.