Besides the high sequence homology, one of the important common features of the Ephexin family is that they are the direct downstream proteins of Eph receptors, the largest subfamily of receptor tyrosine kinases that is activated by Ephrins and involved in various cellular processes such as axon guidance, formation of tissue boundaries, long-term potentiation, angiogenesis, and cancer, through their association with Eph receptors [18,19,20,21,22,23]. Here, NGEF is linked to cancer.