Furthermore, in a preclinical study to investigate the functional role and mechanism of miR-199a-3p in the regulation of cisplatin sensitivities in CCA, Li et al. demonstrated that miR-199a-3p enhances cisplatin activity in CCA cell lines (GBC-SD and RBE) via both inhibiting the mTOR signaling pathway and decreasing the expression of MDR1. This evidence concerns the gene MTOR and cholangiocarcinoma.