In addition to pathways involved in cancer overview, as well as pathways in cancer, proteoglycans in cancer and transcriptional misregulation in cancer, the pathways related to interaction between cell-cell and tumor cells-microenvironment (ECM-receptor interaction, adherens junction, focal adhesion), cell growth and death (p53 signaling pathway and cell cycle), lipid metabolism and signaling transduction (TGF-beta signaling pathway, Hippo signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, mTOR signaling pathway) were significantly enriched in this analysis. The gene discussed is TP53; the disease is cancer.