NR1H4 and steatosis: We found an increased incidence of high ALT and steatosis on imaging in those who had SeHCAT retention <15% (Odds Ratio 2.5).[20] In the study of patients with NAFLD reported here, we hypothesized that they would show abnormalities in the FXR-FGF19 axis, such as an increased incidence of raised C4 and low FGF19, and that by association, there would also be an increased incidence of bile acid diarrhea.