We found an increased incidence of high ALT and steatosis on imaging in those who had SeHCAT retention <15% (Odds Ratio 2.5).[20] In the study of patients with NAFLD reported here, we hypothesized that they would show abnormalities in the FXR-FGF19 axis, such as an increased incidence of raised C4 and low FGF19, and that by association, there would also be an increased incidence of bile acid diarrhea. This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.