ITGAX and obesity due to melanocortin 4 receptor deficiency: Since the carbohydrate intake of HFD was so small that obesity due to HFD did not benefit from SGLT2 inhibitor on the inhibition of the development of pro-inflammatory immune cells including senescent-associated T cells and CD11c+ M1 macrophages, and which might result in no beneficial effect on the chronic inflammation of VAT and glucose metabolism.