Fig 6 and Table 4 display the case of patient LUAD_0000978, from which we can find that KRAS is marked on the edge connected to the root in the phylogenetic tree, indicating its oncogenic role. A previous study analyzing somatic mutation data of non-small cell lung cancer by a different method also found that KRAS and EGFR mutations were present in the founder clone in their results, suggesting that it is likely that these mutations are initiating events for lung cancer [40]. This evidence concerns the gene KRAS and lung carcinoma.