GSTM1 and anemia (phenotype): According to clinical guidelines from the World Health Organization [7], the management of severe anemia (SA) involves: confirmation of the diagnosis via measurement of hemoglobin (Hb) level; investigation of the specific cause of anemia via appropriate diagnostic tests (such as absolute reticulocyte count, blood smear); and prompt provision of a blood transfusion (if indicated) to correct the severe anemia and additional treatment for the specific cause of the SA [7].