In addition to the optimization of pharmacotherapy for T2DM treatment, GUT-DOCK can also be used to design novel active pharmaceutical ingredients (API) which demonstrate agonist/antagonist activity when bound to either orthosteric or allosteric binding sites in the transmembrane domains of GCGR, GIPR, GLP1R, VIPR1 and PAC1R receptors. This evidence concerns the gene GCGR and type 2 diabetes mellitus.