APC and colorectal adenoma: A unique strain of mice at Fox Chase Cancer Center (FCCC) (Apc+/Min-FCCC mice) that spontaneously develops colorectal adenomas at a high multiplicity and high incidence (81.8%), as compared to the conventional Min mouse strain, provides a relevant model for studying colorectal neoplasia; in addition, the extended life-span of the Apc+/Min-FCCC mice provides a sufficient window of opportunity for therapeutic intervention [33].