Robust integration of human photoreceptor precursors in diseased mammalian retina is essential for restoring the visual function and optimizing transplantation therapy; hence, we sought to assess the transplantation capacity of CRX+ hESC‐derived photoreceptor precursors into a model of end stage Retinitis Pigmentosa, Pde6brd1‐C3H mice. This evidence concerns the gene CRX and retinitis pigmentosa.