BAX and coronary artery disorder: Previous studies have shown that statins can promote epigenetic-based control in CVD prevention through histone modifications.[31] In addition, atorvastatin inhibits neointimal formation by inducing p16 expression by inducing DNA methylation in the p16 promoter region.[32] Thus, the decreased BAX methylation in the CHD group may be rescued by drug therapy or other treatment-related factors.