The B-cell lymphoma-2 (BCL-2) family proteins are famous for the capacity for the regulation of programmed cell death.[8] The BCL-2 can prevent cell apoptosis and its over-expression may promote cancer cell survival.[9] Human BCL-2 associated X (BAX) is the 1st death-promoting member in BCL-2 family.[10] The BAX can suppress cell apoptosis process.[8] The expression level of BAX was important for heart disease including CHD. The gene discussed is BAX; the disease is cancer.