BAX and coronary artery disorder: Ageing is a risk factor for multiple chronic diseases.[33] Ageing impacts all organ systems leading to decreased functionality and eventual death.[34] Accumulating evidence has shown that DNA methylation changes are associated with ageing and its related phenotypes.[24,35–38] Our study found that BAX methylation was associated with CHD only among individuals aged over 70, adding a new ageing-related clue of CHD.