NRAS and Miyoshi myopathy: As another context in which to assess the role of the engineered mutation in mouse models of UVR-induced MM, we studied the Trp53F/F::Tyr-Cre(ER)::Tyr-NRAS model in which the Trp53 deletion is induced by tamox application (26) (Figure 1E), whereas in these mice the NRASQ61K mutation is not inducible, so is present through development.