We speculated that DTLL might contribute to inhibition of EGFR‐associated PD‐L1/PD1 signaling, which helped to re‐activate and recruit CD4+/CD8+ effector cells to the tumor microenvironment for killing tumor cells.31, 32 Further characterization studies will be required to elucidate its mechanism of action. The gene discussed is CD4; the disease is neoplasm.