CAD and infantile epileptic encephalopathy: Biallelic variants in the multienzyme complex CAD (carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, CAD, MIM #616457) have recently been reported to lead to a progressive early infantile epileptic encephalopathy with dyserythropoietic anemia and tetraparesis.