Tribbles pseudokinase 3, encoded by TRIB3, has a complex function that is tumor suppressive in some tissue types (Mondal, Mathur, & Chandra, 2016; Salazar, et al., 2015), but has also been linked to disease progression and therapeutic resistance for acute promyelocytic leukemia (Li, Wang, et al., 2017a). The gene discussed is TRIB3; the disease is acute promyelocytic leukemia.