We further explored in TCGA the profile of SDHA alterations (Figure 4a) in the various forms of RCC (clear cell [KIRC], papillary [KIRP], and chromophobe [KICH]), and in other cancers observed in the proband family (including pancreatic adenocarcinoma [PAAD], glioblastoma [GBM], and thyroid cancer [THCA]; note, basal cell carcinoma [BCC] is not represented in TCGA). The gene discussed is SDHA; the disease is cancer.