TJP1 and familial pancreatic carcinoma: Propofol could also reduce intracellular calcium concentration and CAMKII activity in pancreatic cancer cells.39 We demonstrated in this study that propofol may inhibit hypoxia‐induced intracellular calcium accumulation and CAMKII activation as well as ZO‐1 phosphorylation, implying the protective effect was mediated through calcium/CAMKII/ZO‐1 pathway.