Under pathological conditions, TPPP1 is enriched in glial and neuronal inclusions in the synucleinopathies of Parkinson's disease and multiple system atrophy.26, 27, 28 TPPP3 is involved in developmental processes of the musculoskeletal system and is a specific marker of the differentiating tendon sheath and synovial joints.29 These results suggested that TPPP family members might have significant tissue specific expression and thus play an important role in the development and function of specific tissues. This evidence concerns the gene TPPP and Parkinson disease.