TREM2 and Alzheimer disease: Il1b, Arg1, and Nos2 were not altered by IFNAR1 deletion in our study, and these changes along with the suppression of Trem2 in IFNAR1−/− are distinct from profiles in other degenerative models: In the APP/PS1 double transgenic model of AD, disease‐associated increases in mRNA for iNOS were reversed in APP/PS1 × IFNAR1−/− mice, whereas increases in IL‐1 and the “anti‐inflammatory” transcripts for Arg1, TREM2 and TGFβ1 were further increased in the IFNAR1‐deficient mice (Minter et al., 2016).