All type I IFNs can signal via the heterodimeric interferon α/β receptor (IFNAR), which classically signals via a JAK/STAT pathway leading to the upregulation of IFN‐stimulated genes (ISGs) (Schoggins & Rice, 2011), and generation of IFNAR1‐deficient mice (Hwang et al., 1995) has facilitated attempts to understand the role of IFN‐I in neurodegenerative disease. Here, IFNAR1 is linked to neurodegenerative disease.