With respect to chronic neurodegenerative processes, IFNAR1 deficiency resulted in modestly slowed disease progression in SOD1(G93A) model of amyotrophic lateral sclerosis (Wang et al., 2011) and reduced dopaminergic cell death in the MPTP model of Parkinson's disease (Main et al., 2016). Here, IFNAR1 is linked to Parkinson disease.