ACTA1 and cancer: A study showed that the anti-cancer compound minnelide, water-soluble pro-drug of triptolide extracted from Chinese plant Tripterygium wilfordii, disrupted TGF-β signaling and hence reverted activated CAFs to quiescent form by decreasing α-SMA expression, reducing ECM secretion, and increasing vitamin A-containing lipid droplets (Dauer et al. 2018)].