IKBKB and colitis: Another example of tumor-suppressive function of CAFs is that the deletion of nuclear factor kappa B kinase subunit β (IKKβ) in murine model of colitis-associated tumorigenesis resulted in neoangiogenesis and tumor progression showing the tumor-suppressive role of IKKβ (Pallangyo et al. 2015); however, opposite results were shown in the same model by other research group (Koliaraki et al. 2015).