The role of fibroblast in altering the immune-controlled tumor growth was described in transgenic Lewis lung carcinoma and subcutaneous PDAC mouse model, where it was observed that depletion of FAP-expressing cells enhanced the hypoxic necrosis of both tumor and stromal cells by a process involving interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) (Kraman et al. 2010). This evidence concerns the gene TNF and neoplasm.