A study reported that simple blocking of serum amyloid A1 (SAA1), poor prognostic marker in pancreatic cancer cells, did not inhibit tumor growth and they verified two subtypes: saa3-competent and saa3-null CAFs, which showed pro-tumorigenic and anti-tumorigenic effect, respectively (Djurec et al. 2018). This evidence concerns the gene SAA3P and familial pancreatic carcinoma.