Chemotactic cytokines released from a tumor microenvironment i.e. CCL2, CXCL1, CXCL10, PGE2, histamine, VEGF, angiopoietin 1 (Ang1), CXCL8/IL-8 attract mast cells from the vicinity and recruit them from circulation [70]. This evidence concerns the gene CCL2 and neoplasm.