Contrary, M2 TAM are activated with transforming growth factor beta (TGF-β), interleukin 4(IL-4) and interleukin 13 (IL-13) to release a set of growth factors: VEGF, epidermal growth factor (EGF), and fibroblast growth factor (FGF); thus promoting angiogenesis and tumor growth [10]. This evidence concerns the gene VEGFA and neoplasm.