ALPL and adrenal gland hyperfunction: A recent study evaluated the mRNA and miRNA levels in bone samples from Cushing's disease patients with endogenous hypercortisolism.118 Elevated cortisol level is known to associate with accelerated bone loss in both men and women.119 In line with current understanding, among the hypercortisolism patients, bone marker genes, such as RUNX2, BGLAP, and ALPL, were downregulated, whereas expressions of Wnt‐signaling antagonists were found increased.