TP53 and cancer: Members of the miR‐34 family are downstream targets of TP53, a well‐known cancer suppressor.58 The miR‐34 family are involved in a wide range of cellular process.58 Targets of miR‐34 include components of major bone signaling pathways such as Notch and Wnt signaling.59, 60, 61, 62 In vivo mice models showed that miR‐34c regulated osteoclast differentiation by targeting multiple Notch components including Notch1/2 and Jag.