TP53 and osteoporosis: A significant reduction of osteoporosis risk was observed for homozygous CC at rs4938723 (odds ratio [OR] = 0.35, 95% confidence interval [CI] 0.19–0.64; p < 0.001), whereas the TP53 Arg72Pro CC genotype carriers showed a significant increased risk of osteoporosis (OR = 2.21, 95% CI  1.45–3.37; p < 0.001).