TNF and infection: Sufferers of other inflammatory diseases, like inflammatory bowel disease and rheumatoid arthritis, have benefited from treatment with antagonists of TNFα.28, 29, 30 Diabetic wounds have improved with systemic anti‐TNFα therapies31 and antibody‐based neutralization32 but with an increased risk of infection and severe liver damage.30, 32, 33, 34, 35 Local downregulation of TNFα has the potential to correct chronic inflammation in the wound while avoiding the negative side effects associated with systemic suppression of TNFα.